Tag Archives: overdose

Single-Step Naloxone Most Effective in Reversing Overdoses

Naloxone Narcan

Addiction professionals and first responders cope with a lot of variables when responding to an overdose, but nothing has changed the outcomes of emergency calls like Naloxone (also known as Narcan), an opioid antagonist drug that has the power to reverse overdoses. There are several versions of Naloxone delivery available. However, research has revealed that the single-step nasal inhaler seems to be most effective at reversing overdoses, according to new research led by faculty at Binghamton University, State University at New York.

In the past few years, expanded access to naloxone has saved thousands of lives by reversing fatal overdoses in people with opioid use disorder. While many people who overdose are not ready for help yet, others identify the moment their overdose occurred as a pivotal point in their life that helped them choose to get into recovery. Law enforcement and other first responders carry the drug on them all the time, especially in places like Ohio where overdoses take place in parking lots and other public spaces.

There is more than one way to administer Naloxone. Injections can be difficult for the untrained person to deliver, but there is often help available for people who choose to carry the drug. Sometimes injections are required multiple times for serious overdoses, and the skill of the person injecting the drug may come into play when it comes to reversing the drug.

William Eggleston, the clinical assistant professor at the School of Pharmacy and Pharmaceutical Sciences at Binghamton University, wanted to know if everyday people can successfully administer naloxone after basic video training. His research found that for ordinary people who aren’t first responders, the single-step nasal spray was used most successfully with minimal problems.

Eggleston conducted a study to estimate and compare the rate of successful administration and the time to successful administration by community members for single-step nasal spray, multi-step atomized nasal spray, and intramuscular simulated naloxone.

For the study, and over the course of several days, 138 adults with no prior naloxone training were asked to watch a two-minute video teaching them how to administer the drug. For each type of administration, they were asked to the adminster the reversal drug on a dummy.

After the video training, participants were able to administer the single-step nasal spray naloxone with a higher rate of success than the other types. This information is important for community naloxone programs across the United States.

“With training, nasal sprays, in general, had a higher degree of success than the shot,” Eggleston said. “Even if it seemed to us it was a no-brainer that we should be using nasal sprays, we had no data before, so now we have some to support that.”

Many people don’t realize it, but Naloxone has also been used to help people who have overdosed on other drugs such as synthetic marijuana and benzodiazepines.

The cost of the single-step Narcan spray is about $140, making it more cost prohibitive than the injection, which is about $40.

Image courtesy and copyright Adapt Pharma.

Fentanyl-Cocaine Combo Causing Deaths in MD

Image shows an empty hospital bed.

In Maryland, the government has been doing its best to fight the addiction crisis, but they’re not yet winning: in 2017, the number of fatal overdoses increased 9%. Most of these overdoses (90%) were considered to be opioid-induced, with Fentanyl overdoses increased by 42 percent last year, rising from 1,119 in 2016 to 1,594. Fentanyl is a drug that is 50 times stronger than heroin and is typically used in a medical setting. When added to other street drugs, it can be deadly, especially if novice opioid users are taking the drug. In Maryland, they have discovered that a fentanyl-cocaine combination of drugs is causing deaths. Between 2015 and 2016, cocaine deaths doubled because of this lethal combination.

The Maryland Department of Health Secretary Rober R. Neall called the increase in fentanyl-related deaths “staggering.” Officials think that the overdose deaths of cocaine containing fentanyl were accidental; the user may have had no clue that the two drugs were combined. Over 71% of cocaine deaths in 2017 was due to the fatal combination.

These deaths did not seem to have anything in common other than they were accidental. State officials say that the increase in cocaine deaths took place across demographics, affecting all age groups and both genders almost equally.

Heroin overdose deaths have also been decreased in the last year. In 2016, they had amounted to 58% of overdose deaths in the state.

In 2017, the amount of drug fatalities hit an all-time high in Maryland, although the actual increase in drug deaths was just 9%. This number compares to a 66% increase from 2016 to 2017. So it’s possible that efforts to combat fatal overdoses are working. One way the state is helping prevent these overdoses is via Narcan, an opioid antagonist that can help reverse overdoses. They are available both to first responders as well as over-the-counter for residents that have taken the training online.

 

 

Fake Street Pills Made With Deadly Opiates Now Common

overdose on fake street pills

People addicted to Oxycontin often resort to desperate measures, including buying their pills on the street. Unfortunately, addicted persons who buy these pills are discovering that they’re fake street pills. They are now being linked to carfentanil and cyclopropyl fentanyl overdoses in New Jersey and across the country.  New Jersey is just one of many states that has experienced deadly incidents of street pills – typically sold as Oxycontin or Hydrocodone — giving their users more than they bargained for.

Luckily, in Holmdel and Long Branch New Jersey, investigators were able to seize the pills before anyone got hurt – as far as they know, anyway. (It takes months for a state Bureau of investigation to tally the figures that include deaths from any illicit drugs.) The seizure was made last week, and the oxycodone pills were found to not contain oxycodone at all. In fact, they contained carfentanil, a synthetic opiate that is 10,000 times as strong as morphine. The drug is so strong that a non-drug user can experience an overdose if just a speck or two is absorbed through their skin. It’s used to sedate elephants and is entirely unsafe for people.

Some of the fakes seized in New Jersey also contained cyclopropyl fentanyl, which has no known medical use for humans or animals and is said to be about 50 times stronger than heroin.

Cyclopropyl fentanyl is also a dangerous new trend among street pills fakes – like carfentanil, it’s a powerful opioid. While recently found in New Jersey, this drug is tied to several mass overdose incidents across the US. Georgia linked the drug to an incident that flooded emergency rooms for 48 hours last July, with several fatal overdoses that never made it to the hospital.

Fake pills are often sold on the street, and US authorities suspect they originate in China. The carfentanil and cyclopropyl fentanyl pills found in Monmouth County, New Jersey were meant to masquerade as Oxycodone, and both were a bright white pill marked A/215, the same number that prescription drug website show as Oxycodone.

There is virtually no way for drug users to differentiate fake street pills from real pills, although sometimes they crumble easily or have a tinge of yellow, according to authorities.

These powerful and deadly opiates have also found their way into heroin as well.

If someone you know and love is addicted to prescription painkillers or opioids, it’s important to encourage them and/or their friends to carry naloxone, a lifesaving opiate antagonist that can reverse an overdose. Let them know there is help whenever they are ready, and encourage them to contact a treatment or 12-step hotline to explore their options. Sometimes a list of phone numbers kept in their wallet may be effective to help them when they’re desperate and in need of a person who understands what they’re going through.

People do get clean, and they do recover.

2C-I or “Smiles” Linked to Recent Deaths

johnny lewis smiles 2c-iAuthorities are investigating whether a new designer drug played a role in a gruesome Los Angeles homicide that involved a young actor.

Johnny Lewis, who appeared in the series “Sons of Anarchy,” is suspected of being under the influence of 2C -I (also known as “Smiles”) when he allegedly beat his 81-year-old landlady to death and then attacked a neighbor. The neighbor managed to escape and Lewis was later found dead by police after he apparently fell from a wall at the neighbor’s house.

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A Mother’s Loss Influences Oxy Legislation

Legislative Action Comes in Memory of Ryan Creedon

Ryan Creedon overdosed on OxyContin on September 4, 2009, he was only 21. Creedon fell into the alarming national trend of abusing prescription pills.

Creedon’s mother, Kathy Creedon said that Ryan would run around Palm Desert California, from doctor’s office to doctor’s office to refill his Oxy prescriptions.

Creedon’s mother said, “It’s like watching your child slowly kill themselves. By the time he was 18 or 19, he had started using prescription medications like OxyContin.”

She also pointed out that it was an addiction that was not easily hidden.
“Every time he would get a job, he would go to work under the influence or he was stealing to support his habit,” said Creedon’s mother. 

What bothered Creedon’s mother the most was how easy it was for Creedon to get his prescription medication. “He went from one end of this valley to the other, getting pills form one doctor, one hospital to another doctor.”

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Acclaimed Jockey Michael Baze Dead from Cocaine Overdose in Kentucky

michael baze cocaine overdose victimMichael Baze, 24, was found dead in his car on May 10 near the Churchill Downs stables in Louisville Kentucky. The toxicology report given by Jefferson County Deputy Coroner Jim Wesley on Friday, said that Baze died from multiple substance intoxication.

The Toxicology report stated that a significant amount of cocaine was in Baze’s system. There was also a significant amount of oxymorphone, which is a pain medication sold under the brand name of Opana.

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Elderly Man Overdoses after Drinking Heroin Tea

On August 21 of last year police found Nicholas Tyrrell, 51, dead in his apartment. A concerned neighbor, Ronald Potter, called the police after he had not seen Tyrrell for four days. An inquest heard last week said that Tyrrell had fatal levels of morphine in his system, which pointed to the misuse of heroin.

Tyrrell had been experiencing anxiety and depression for a number of years. He would drink tea that contained crushed opium poppy seeds that he would purchase on -line. There was one point in time were Tyrrell sought help and stopped the habit, but then he lapsed.

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